Process for producing antibiotics MA 144-M.sub.1 and MA 144-M.su

Details Process for producing antibiotics MA 144-M.sub.1 and MA 144-M.su Process for producing antibiotics MA 144-M.sub.1 and MA 144-M.su

1979-03-05

1980-08-26

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435886, 435888, 435189, C12P 1956

Patent

active

042196221

ABSTRACT:
New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

REFERENCES:
patent: 3864480 (1975-02-01), Wang et al.
patent: 3988315 (1976-10-01), Umegawa et al.
patent: 4127714 (1978-11-01), Umezawa et al.
Keller-Schublein et al., Antimicrobial Agents and Chemotherapy, pp. 68-77 (1970).
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J. Antibiotics 28:830 (1975).
Chem. Ber. 92:1904-1909 (1959).
Biochem J. 81:101-104 (1961).
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Chemical Abstracts 643896g (1966).
Chemical Abstracts 67:90573z (1967).
J. Bacterial 72:90-94 (1956).
J. Antibiotics 25:393-399 (1972).
Index of Antibiotics from Actinomyces, Umezawa Univ. Park Press, pp. 111, 220, 221, 542 (1967).
Antibiotics, vol. 1, Mechanism of Action Springs Vendag, New York, Inc., pp. 190-210 (1967).
Information Bulletin No. 10, International Center of Information of Antibiotics in Collaboration with WHO 12/1972.
J. Am. Chem. Soc. 86:3592-3594 (1964).
Arch. fur Mikrobiol 31:356-358 (1958).
International Journal of Systematic Bacteriology 22:298 (1972).

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