Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-07-01
1996-01-09
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548255, 5482648, 5482654, 5482656, 5483265, 5483351, 5483741, 514383, 514398, 514407, A61K 3141, A61K 31415, C07D24906
Patent
active
054829542
ABSTRACT:
A discovery underlying this invention is the concordance between particular cellular signaling mechanisms and cancer cell growth and metastasis. It has now been discovered that certain compounds inhibit the signal transduction required for the maintenance and driving of the malignant process. These compounds are also effective for the in vivo treatment of solid tumors and related disease states. This invention provides a method for the use of these compounds to inhibit the invasion and metastasis of malignant solid tumors in mammals. This invention further provides a method for using related compounds to treat diseases involving aberrant signal transduction pathways. Some of the compounds used in the methods of the present invention are novel and constitute another aspect of this invention.
REFERENCES:
patent: 4299834 (1981-11-01), Austel
patent: 4590201 (1986-05-01), Bochis
patent: 4659720 (1987-04-01), Chabala
patent: 4816469 (1989-03-01), Bochis
patent: 4847257 (1989-07-01), Hupe et al.
patent: 5132315 (1992-07-01), Kohn
Lovelette, C. A., et al., "Studies in nonbridgehead Fused Nitrogen Heterocycles. Fused 1,2,3-Triazoles", J. Org. Chem., vol. 37, No. 25, pp. 4124-4128, 1972.
Hamilton, Thomas C., et al., "Characterization of a Xenograft Model of Human Ovarian Cancer Which Produces Ascites and Intraabdominal Carcinomatosis in Mice", Cancer Research, vol. 44, pp. 5286-5290, 1984.
Allen, Lee F., et al. "G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the .alpha..sub.1B -adrenergic receptor enhances mitogenesis and tumorigenicity", Proc. Natl. Acad. Sci. USA, vol. 88, pp. 11354-11358, 1991.
Julius, David, et al., "Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation", Science, vol. 244, pp. 1057-1062, 1989.
Jelsema, Carole L., et al., "Stimulation of phospholipase A.sub.2 activity in bovine rod outer segments by the .beta..gamma. subunits of transducin and its inhibition by the a subunit", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 3623-3627, 1987.
Liotta, Lance A., et al., "Tumor cell autocrine motility factor", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 3302-3306, 1986.
Gutkind, J. Silvio, "Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes", Proc. Natl. Acad. Sci. USA, vol. 88, pp. 4703-4707, 1991.
Landis, Claudia, A., et al., "GTPase inhibiting mutations activate the .alpha. chain of G.sub.S and stimulate adenylyl cyclase in human pituitary tumours", Nature, vol. 340, pp. 692-696, 1989.
Fleischman, Laurie, F., et al., "Ras-Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-bisphosphate and Catabolites", Science, vol. 231, pp. 407-410, 1986.
Alonso, Teresa, et al., "Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways", Proc. Natl. Acad. Sci. USA, vol. 85, pp. 4271-4275, 1988.
Pozzatti, R., et al., "Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials", Science, vol. 232, pp. 223-227, 1986.
Jackowski, Suzanne, et al., "A Guanine Nucleotide-dependent Phosphatidylinositol 4,5-Disphosphate Phospholipase C in Cells Transformed by the v-fms and v-fes Oncogenes", The Journal of Biological Chemistry, vol. 261, No. 11, pp. 4978-4985, 1986.
Church, Jon G., "G-protein-mediated Epiderma Growth Factor Signal Transduction in a Human Breast Cancer Cell Line", The Journal of Biological Chemistry, vol. 263, pp. 4242-4246, 1988.
Ashkenazi, Avi, et al., "Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes", Letters to Nature, pp. 146-150, 1989.
Young, Dallan, et al., "Isolation and Characterization of a New Cellular Oncogene Encoding a Protein with Multiple Potential Transmembrane Domains", Cell, vol. 45, pp. 711-719, 1986.
Kohn, Elise, C., et al., "In Vivo Efficacy of a Novel Inhibitor of Selected Signal Transduction Pathways Including Calcium, Arachidonate, and Inositol Phosphates", Cancer Research, vol. 52, pp. 3208-3212, 1992.
Stracke, Mary, L., et al., "Pertussis Toxin Inhibits Stimulated Motility Independently of the Adenylate Cyclase Pathway in Human Melanoma Cells", Biochemical and Biophysical Research Communications, vol. 146, No. 1, pp. 339-345, 1987.
Allende, Jorge, E., "GTP-mediated macromolecular interactions: the common features of different systems", pp. 2356-2367, 1989.
Neer, Eva J., et al., "Roles of G Protein subunits in transmembrane signaling", Nature, vol. 333, pp. 129-134, 1988.
Berridge, Michael, J., et al., "Inositol Trisphosphate and Diacylglycerol: Two Interacting Second Messengers", Ann. Rev. Biochem., vol. 56, pp. 159-193, 1987.
Hupe, Donald J., et al., "The Inhibition of Receptor-mediated and Voltage-dependent Calcium Entry by the Antiproliferative L-651,582", The Journal of Biological Chemistry, vol. 266, No. 16, pp. 10136-10142, 1991.
Kohn, Elise, C., et al., "Autocrine Motility Factor Stimulates a Three-Fold Increase in Inositol Trisphosphate in Human Melanoma Cells", Biochemical and Biophysical Research Communications, vol. 166, No. 2, pp. 757-764, 1990.
Kohn, Elise, C., et al., "Autocrine Motility Factor Stimulates Phosphatidyl-Inositol Turnover in Human Melanoma Cells", Proceedings of AACR, vol. 29, 1988.
Kohn, Elise, C., et al., "L651582: A Novel Antiproliferate and Antimetastasis Agent", Journal of the National Cancer Institute, vol. 82, No. 1, 1990.
Kohn, Elise, C., et al., "L651582, A Novel Antiproliferate and Antimetastasis Agent Which Interferes with Guanine Nucleotide-Binding Protein Function", Journal of the National Cancer Institute, vol. 82, No. 1, 1990.
Merritt, Janet E., et al., "SK&F 96365, a novel inhibitor of receptor-mediated calcium entry", Biochem. J., vol. 271, pp. 515-522, 1990.
Felder, Christian C., et al., "The Antiproliferative and Natimetastatic Compound L651582 Inhibits Muscarinic Acetylcholine Receptor-Stimulated Calcium Influx and Arachidonic Acid Release", Journal of Pharmacology and Experimental Therapeutics, vol. 257, No. 23, pp. 967-971, 1991.
Jones, David, T., et al., "Biochemical Characterization of Three Stimulatory GTP-binding Proteins", The Journal of Biological Chemistry, vol. 265, No. 5, pp. 2671-2676, 1990.
Felder Christian C.
Kohn Elise C.
Liotta Lance A.
Gupta Yogendra N.
The United States of America as represented by the Department of
LandOfFree
Signal transduction inhibitor triazole and diazole compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Signal transduction inhibitor triazole and diazole compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Signal transduction inhibitor triazole and diazole compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1303345