Stabilized pharmaceutical peptide compositions

Details Stabilized pharmaceutical peptide compositions Stabilized pharmaceutical peptide compositions

1993-06-29

1996-01-09

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 12, 530315, A61K 3800, C07K 1400, C07K 716

Patent

active

054829313

ABSTRACT:
Disclosed is a stabilized aqueous composition for administration to a patient comprising a biologically active peptide, a buffer, a quaternary amine-type preservative or disinfectant, and an osmotic pressure-controlling agent, which composition can be stored and used at room temperature. The buffer stabilizes the pH of the composition between about 4 and 6. The preferred buffer contains citrate and/or phosphate, and the preferred preservative or disinfectant is benzalkonium chloride. The composition protects the peptide contained therein from adhering to container surfaces, particularly in containers made of polymeric materials.

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patent: 5124315 (1992-06-01), Ceschel et al.

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