Process for bromination of pyrimidine

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D23930

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039563014

ABSTRACT:
The process for brominating pyrimidine which comprises reacting bromine at an elevated temperature with the hydrogen halide addition salt of pyrimidine in an organic solvent substantially inert to the action of bromine under the conditions of the process. The process is also shown to be applicable to other nitrogen-containing heterocycles.

REFERENCES:
bredereck et al., Chem. Ber. 91 pp. 2832-2848 (1958).
Bredereck et al., Chem. Ber. 95, pp. 803-808 (1962).
Tetrahedron Letters, 22, pp. 2183-2186 (1972).
Gilman, et al., J. Am. Chem. Soc. 69, p. 1946 (1947).
Rec. Tran. Chem. 84 pp. 1101-1108 (1965).
J. Org. Chem. 27, pp. 1318-1323 (1962).

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