DNA encoding human 5-HT.sub.1D receptors

Details DNA encoding human 5-HT.sub.1D receptors DNA encoding human 5-HT.sub.1D receptors

1990-05-08

1992-10-13

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 29, 435 34, 435 691, 435 703, 435 712, 435 91, 4351723, 4352402, 4353201, 435820, 436501, 436503, 436 86, 436811, 935 9, 935 18, 935 29, 935 34, 935 70, 935 72, 935 78, C07H 2104, C12Q 168

Patent

active

051552183

ABSTRACT:
This invention provides isolated nucleic acid molecules encoding human 5-HT.sub.1D receptors, isolated proteins which are human 5-HT.sub.1D receptors, vectors comprising isolated nucleic acid molecules encoding human 5-HT.sub.1D receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT.sub.1D receptors, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT.sub.1D receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT.sub.1D receptor, pharmaceutical compounds related to human 5-HT.sub.1D receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT.sub.1D receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT.sub.1D receptor.

REFERENCES:
patent: 4985352 (1991-01-01), Julius et al.
Zabel et al. (1983) Proc. of Nat'l. Acad. Sci. (U.S.A.), vol. 80, 6932-6936.
Julius et al. (1988) Science, vol. 241, pp. 558-564.
Libert et al. (1989) Science, vol. 244, pp. 569-572.

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