2-[4-(P-Aminobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyr

Details 2-[4-(P-Aminobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyr 2-[4-(P-Aminobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyr

1977-07-20

1978-11-14

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544279, A61K 31505, C07D40114

Patent

active

041256158

ABSTRACT:
2-[4-(P-Aminobenzyl)-1-piperazinyl]-8-ethyl-5,8-dihydro-5-oxopyrido-[2,3-d] pyrimidine-6-carboxylic acid, and its pharmaceutically acceptable salt. This novel compound can be prepared by reacting a compound of the formula ##STR1## wherein R is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, with a compound of the formula ##STR2## wherein R.sub.1 is an amino group or a group convertible to the amino group, and X is a reactive moiety capable of splitting off together with the hydrogen atom at the 4-position of the 1-piperazinyl group of the compound of the formula (II). Pharmaceutical compositions containing aforesaid compounds as active ingredients are useful for treating a bacterial infection of man and other warm-blooded animals.

REFERENCES:
patent: 3320257 (1967-05-01), Lesher
patent: 3673184 (1972-06-01), Minami et al.
patent: 3770742 (1973-11-01), Matsumoto et al.
patent: 3887557 (1975-06-01), Minami et al.
patent: 3950338 (1976-04-01), Pesson
patent: 3992380 (1976-11-01), Lesher et al.
Shimizu, et al., "Antimicrobial Agents and Chemotherapy", 1970, pp. 117-122.
Shimizu, et al., "Antimicrobial Agents and Chemotherapy", vol. 9, No. 4, 1976, pp. 569-574.

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