Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1990-06-28
1992-10-13
Warden, Robert J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524025, 43524046, C12N 502
Patent
active
051550350
ABSTRACT:
A bio-reactor system wherein a tubular housing contains an internal circularly disposed set of blade members and a central tubular filter all mounted for rotation about a common horizontal axis and each having independent rotational support and rotational drive mechanisms. The housing, blade members and filter preferably are driven at a constant slow speed for placing a fluid culture medium with discrete microbeads and cell cultures in a discrete spatial suspension in the housing. Replacement fluid medium is symmetrically input and fluid medium is symmetrically output from the housing where the input and the output are part of a loop providing a constant or intermittent flow of fluid medium in a closed loop.
REFERENCES:
patent: 3647632 (1972-03-01), Johnson et al.
patent: 3676074 (1972-07-01), Shibayama et al.
patent: 4184916 (1980-01-01), Tolbert et al.
patent: 4244916 (1981-01-01), Guigan
patent: 4264739 (1981-04-01), Grabner et al.
patent: 4276384 (1981-06-01), Mueller
patent: 4310630 (1982-01-01), Girard et al.
patent: 4343904 (1982-08-01), Birch et al.
patent: 4535062 (1985-08-01), Muller
patent: 4537860 (1985-08-01), Tolbert et al.
patent: 4596779 (1986-06-01), Ono
patent: 4605626 (1986-08-01), Beck
patent: 4649117 (1987-03-01), Familletti
patent: 4649118 (1987-03-01), Anderson
Block et al., "Gravisensitivity of the acellular slime mold Physarum polycephalum demonstrated on the fast-rotating clinostat". European Journal of Cell Biology, vol. 41 (Dec. 30, 1985), pp. 44-50.
Briegleb. "The Clinostat-A Tool for Analysing the Influence of Acceleration on Solid-Liquid Systems." Institute for Aerospace Medicine, Proceedings of a Workshop, Cologne, Germany, Mar. 9-11, 1983, pp. 97-101.
Feder et al. "The Large-Scale Cultivation of Mammalian Cells." Scientific American, vol. 248, No. 1 (Jan. 1983), pp. 36-43.
Fowlis et al. "Particle Orbits in a Rotating Liquid." Space Science Laboratory, NASA Marshall Space Flight Center, Huntsville, AL 35812.
Lewis et al. "Growth and Maintenance of Anchorage Dependent Cells in Zero Headspace Bioractor Systems Designed for Microgravity." Spacebound Proceedings Abstract (May 6-8, 1987).
Lewis et al. "Growth and Maintenance of Anchorage Dependent Cells in Zero Headspace Bioractor Systems Designed for Microgravity." Spacebound Proceedings Paper (Sep. 14, 1987).
Schwarz Ray P.
Wolf David A.
Beisner William H.
Fein Edward K.
Miller Guy M.
Schlorff Russell E.
The United States of America as represented by the Administrator
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