Polymeric immunoregulatory agents containing half-amide/half car

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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525378, 528322, 528335, C08F 830

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active

042555370

ABSTRACT:
The disclosure relates to copolymers of olefin monomers having from 2 to about 4 carbon atoms and .alpha.,.beta.-unsaturated polycarboxylic anhydrides having from 4 to about 6 carbon atoms, having an average molecular weight of from about 300 to about 1500, and derivatized to contain both a half-amide, half-carboxylate salt function and an imide function in which said imide function comprises from about 5% to about 40% of said derivatized function.
The utility of these copolymers in the management of tumor therapy to prevent tumor recurrence or development of metastases by an immunoregulatory mechanism has been demonstrated in rats and mice.

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Advances in Cancer Research-Regelson, vol. 11, (1968), pp. 223-226, 240-241.
Nature-Regelson et al., vol. 186, (1960), pp. 778-780.
Polymeric Science and Technology-Regelson, vol. 2, (1973), pp. 161-168.
Pure and Applied Chemistry-Breslow, vol. 46, (1976), pp. 103-113.

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