Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q

Details Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q

1980-02-19

1981-11-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546153, C07D45504, C07D21522

Patent

active

043012892

ABSTRACT:
An improved process for preparing the antimicrobial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50.degree. and 60.degree. C. In the second step, the product of the first step is treated to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydroquinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.

REFERENCES:
patent: 3896131 (1975-07-01), Gerster
Jones, et al., J. Chem. Soc. Trans. 97, pp. 632-644 (1910).
Elderfield, et al., J. Am. Chem. Soc., vol. 71, pp. 1906-1911 (1949).
Mirek, Chemical Abstracts, 62, 5252b (1965).
Palmer, The Structure and Reactions of Heterocyclic Compounds, Edwin Arnold, Ltd., London, (1967), pp. 110-111.

Affiliated with

Also associated with

Rating

Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)q will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1293546