Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1979-12-17
1981-11-17
Brust, Joseph Paul
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546220, 546221, 546242, 546116, 424256, C07D491113
Patent
active
043012876
ABSTRACT:
The compound Ia ##STR1## has been shown to possess GABA-related activity. The invention relates to Ia and derivatives thereof, covered by the formula ##STR2## in which R" is hydrogen, acetyl or a group of the general formula VII ##STR3## in which R.sub.5 is C.sub.1-8 alkyl; phenyl; phenyl substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; or phenylalkyl in which the phenyl group may be substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; and salts thereof. Novel intermediates for preparing I are ##STR4## in which Alk is a lower alkyl group and Z is hydrogen or an amino-protecting group; ##STR5## wherein Z is hydrogen or an amino-protecting group, T is a group convertible, by hydrolysis, into an oxy group, and Q is a leaving group which, on reaction with hydroxylamine, forms a hydroxamic acid group; ##STR6## wherein Z and T are as defined above; ##STR7## wherein Z is as defined above, and W is hydrogen or a group removable to yield the free hydroxy group, with the proviso that at least one of Z and W is different from hydrogen.
REFERENCES:
patent: 2784190 (1957-03-01), Nathan et al.
patent: 3186991 (1965-06-01), Ohnacker
Prill et al.; Jour. Amer. Chem. Soc.; 55; (1933), pp. 1233-1241.
Howton; Jour. Org. Chem.; 10(4), (1947); pp. 277-282.
Brust Joseph Paul
H. Lundbeck & Co. A/S
Hueschen Gordon W.
LandOfFree
Heterocyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1293533