Peptide synthesis reagents and method of use

Details Peptide synthesis reagents and method of use Peptide synthesis reagents and method of use

Filed on

1982-05-12

Date issued

1985-03-26

Examiner

Phillips, Delbert R.

Patent Class

Chemistry of carbon compounds

SubClass

Miscellaneous organic carbon compounds

SubSubClass

C-metal

Other Related Categories

525 5411, C07C10352, C08L 8900

Type

Patent

Status

active

Patent number

045072302

Description

ABSTRACT:
A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF and a base for a time and under conditions effective to produce the release; wherein the amounts of HF and base in the mixture are adjusted so that said release occurs substantially by an S.sub.N 2 mechanism.

REFERENCES:
patent: 4062815 (1977-12-01), Hughes et al.
Tam et al., J. Am. Chem. Soc., 105(21), 6442-6455, (1983).
Lenard et al., J. Am. Chem. Soc., 89:1, pp. 181-182, (1967).
Chemical Abstracts, 73, 383 (1970), Abstract No. 88152s.
The Merck Index, 9th ed., Merck and Co. Inc., Rahway, N.J. 1976.
Solomons, Organic Chemistry, John Wiley and Sons, N.Y. p. 650, (1978).
Yoshihiro et al., Bull. Chem. Soc. Jpn., 53, 464-468, (1980).

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