Process for the purification of glucosaminoglucans

Details Process for the purification of glucosaminoglucans Process for the purification of glucosaminoglucans

1981-02-25

1985-03-26

Spear, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210651, B01D 1300

Patent

active

045072051

ABSTRACT:
A process for the removal of components having low or no anticoagulant activity from a glucosaminoglucan is described which comprises subjecting said glucosaminoglucan in the form of a salt in an aqueous solution to flow across a membrane suitable for ultrafiltration, hyperfiltration (inverse osmosis) or dialysis with partial passage through said membrane, whereby fractions of low activity go through the membrane and fractions of higher activity do not go through the membrane and are concentrated. The membrane suitable for ultrafiltration may have a nominal molecular cut-off between 1000 and 15,000. The membrane suitable for dialysis may have a nominal molecular cut-off at less than 30,000. The glucosaminoglucan may be heparin in the form of the sodium or calcuium salt.

REFERENCES:
patent: 3228877 (1966-01-01), Mahon
patent: 3817831 (1974-06-01), Mancilla et al.
Michaels, "New Separation Technique for the CPI", from Chem. Eng. Progress, vol. 64, No. 12, pp. 31-43.
Porter et al., "Membrane Ultrafiltration", from Chem. Tech., 1-1971, pp. 56-63.

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