Synergistine derivatives having anti-bacterial activity and thei

Details Synergistine derivatives having anti-bacterial activity and thei Synergistine derivatives having anti-bacterial activity and thei

1984-07-12

1986-10-21

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3702, C07K 512

Patent

active

046185992

ABSTRACT:
The invention provides new synergistine derivatives of the formula: ##STR1## in which Y=H or N(CH.sub.3).sub.2 and (a) R.sub.1 and R.sub.2 =H and R=pyrrolidin-3-ylthio or piperidin-3-ylthio or piperidin-4-ylthio (optionally substituted by alkyl), or altenatively R=alkylthio substituted by 1 or 2 SO.sub.3 H radicals or alkylamino or dialkylamino radicals (optionally substituted) or by 1 or 2 piperazino rings (optionally substituted) or morpholino, thiomorpholino, piperidino, pyrrolidin-1-yl, piperidin-2-yl, piperidin-3-yl or piperidin-4-yl or pyrrolidin-2-yl or pyrrolidin-3-yl rings (these last 5 rings being optionally substituted by alkyl), or

REFERENCES:
J. Preud'homme, P. Tarridec and A. Belloc, pp. 585-591, (1967).
Chem. Abstr. vol. 99, (1983) 212905.
Chem. Abstr. vol. 76, (1972) 127404.
Chem. Abstr. vol. 63, (1965) 13408.
Merck Index, 9th Edition (1976), "Mikamycin and Virginiamycin".
Preud'homme et al. Article.
Mutton et al. (Chemotherapy 29), (1983).
Mattei et al., La Presse Medicale 29, 1789 (1984).
Rollmann et al., Pharm. Acta Helv. 50(12) 455(1975).

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