Method of regulating hormone function or release

Details Method of regulating hormone function or release Method of regulating hormone function or release

1982-04-12

1986-10-21

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 12, 514 13, 514874, 435 7, 530313, 530399, A61K 3700, A23J 700, C07K 100, G01N 5300

Patent

active

046185984

ABSTRACT:
A synthetic hormone complex comprising means for binding to the surface of a cell and means for altering second messenger mobilization by the cell. One form of the synthetic hormone complex functions as an antagonist with specific binding affinity for a cell receptor, said hormone in combination with a calcium ion channel inhibitor. Another synthetic hormone complex functioning as an Agonist comprising two or more molecules of a hormone having specific binding affinity for a cell receptor wherein a spacer binding the hormones is 10 to 300 angstroms in length. A method of regulating hormones or other regulatory factors comprising contacting a synthetic hormone complex with a cell surface or internal receptor thereby altering the incorporation of second messenger molecules thereby regulating the physiological function of the cell.

REFERENCES:
Conn et al., Endocrinology, 1979, vol. 105, pp. 1122-1127, "Alteration of the Intracellular . . . Rat Anterior Pitu. Cells".
Conn et al., Endocrinology, 1980, vol. 107, pp. 2133-2134, "Gonadotropin Release from Pituitary Culture".
Conn et al., J. Biol. Chem (Feb. 10, 1981) pp. 1098-1100, "Stimulation of Pituitary Gonodotropin Release".
Conn et al., (including Deloris C. Rogers, M. Stewart, James Niedel, and Timothy Sheffeld) Nature, Apr. 15, 1982, pp. 653-655.
The Merck Index, 9th Edition, pp. 425, 298, 848, 1002, and 1277.

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