N-Substituted aziridine-2-carboxylic acid derivatives and their

Details N-Substituted aziridine-2-carboxylic acid derivatives and their N-Substituted aziridine-2-carboxylic acid derivatives and their

1981-12-28

1983-10-18

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 544242, 544255, 546115, 546275, A61K 3144, C07D20308, C07D21336

Patent

active

044105320

ABSTRACT:
A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy;
or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

REFERENCES:
Wagner-Jauregg et al., Chem. Abst. 15271C, vol. 59, (1963).
Capeller et al., Chem. Abst. 7262g & 7263a, vol. 52 (1958).
Kampe et al. I, Chem. Abst. 109037, vol. 89 (1978).
Kampe et al. II, Chem. Abst. 136445, vol. 88 (1978).
Gundermann et al. I Berichte 105, 312-324.
Gundermann et al. II Berichte 93, 1632.
Burzen, Chem. Abs. 86, 171430.

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