Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-03-31
1998-09-08
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142315, 514269, 514278, 514314, 514326, 544 60, 544111, 544333, 544335, 546 16, 546 17, 546135, 546256, A01N 4354, C07D41300, C07D21500, C07D45302
Patent
active
058045783
ABSTRACT:
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
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Chakravarty Prasun K.
Chen Meng H.
Nargund Ravi
Patchett Arthur A.
Tata James R.
Merck & Co. , Inc.
Ngo Tamthom T.
Rose David L.
Shah Mukund J.
Thies J. Eric
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