Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-07-07
1998-09-08
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530326, 424405, 536 235, 435 691, 4352523, 4353201, 935 9, 935 27, 935 66, A61K 3804, A01N 2500, C12N 1512, C12N 1513
Patent
active
058045589
ABSTRACT:
Peptide-based compounds containing four invariant cycteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula: ##STR1## and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally -SH stabilized linear or in a cystine-bridged form
REFERENCES:
patent: 4543252 (1985-09-01), Lehrer et al.
patent: 4652639 (1987-03-01), Stabinsky
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5087569 (1992-02-01), Gabay et al.
patent: 5126257 (1992-06-01), Gabay et al.
patent: 5171739 (1992-12-01), Scott et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5338724 (1994-08-01), Gabay et al.
patent: 5422424 (1995-06-01), Selsted et al.
patent: 5432270 (1995-07-01), Zasloff et al.
patent: 5447914 (1995-09-01), Travis et al.
patent: 5458874 (1995-10-01), Pereira et al.
patent: 5459235 (1995-10-01), Selsted et al.
patent: 5464823 (1995-11-01), Lehrer et al.
patent: 5484885 (1996-01-01), Pereira et al.
Lerner, R. A., Nature, vol. 299, "Tapping the immunological repertoire to produce antibodies of predetermined specificity", pp. 592-596, 1982.
Matsumoto, S., Chemical and Pharmaceutical Bulletin, vol. 40, "Amino acids and peptides. XXXV. Synthesis of mouse metallothionein", pp. 2701-2706, 1982.
Selsted, M. E., et al., The Journal of Biological Chemistry, vol. 260, "Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils", pp. 4579-4584, 1985.
Robson, B., & Garnier, J., in Introduction to Proteins and Protein Engineering, Elsevier, New York, "The concept of primary structure", pp. 27-46, 1986.
Pongor, S., Methods in Enzymology, vol. 154, "The use of structural profiles and parametric sequence comparison in the rational design of polypeptides", pp. 450-473, 1987.
Olsson, U., et al., Biochimica et Biophysica Acta, vol. 1097, "Molecular parameters that control the association of low density lipoprotein apo B-100 with chondrotin sulfate", pp. 37-44, 1991.
Matsuzaki, K., et al., Biochimica et Biophysica Acta, vol. 1070, "Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes", pp. 259-264, 1991.
Bateman, A., et al., Peptides, vol. 13, "The levels and biologic action of the human neutrophil granule peptide HP-1 in lung tumors", pp. 133-139, 1992.
Selsted, M. E., et al., The Journal of Cell Biology, vol. 118, "Enteric defensins: Antibiotic peptide components of intestinal host defense", pp. 929-936, 1992.
Park, N. G. et al., Biochemistry, vol. 31, "Conformation of tachyplesin I from Tachypleus tridentatus when interacting with lipid matrices", pp. 12241-12247, 1992.
Masuda, M. et al., Biochemical and Biophysical Research Communications, Lys7!-polyphemusin II)", pp. 845-850, 1992.
Tamamura, H., et al., Chemical and Pharmaceutical Bulletin, vol. 41, "Antimicrobial activity and conformation of tachyplesin I and its analogs", pp. 978-980, 1993.
Tamamura, H., et al., Biochimica et Biophysica Acta, vol. 1163, "A comparative study of the solution structure of tachyplesin I and a novel anti-HIV synthetic peptide, T22, determined by nuclear magnetic resonance", pp. 209-216, 1993.
Schluessener, H. J., et al., Journal of Neuroimmunology, vol. 47, "Leukocyte antimicrobial peptides kill autoimmune T cells", pp. 199-202, 1993.
Harwig, S. S. L., et al., FEBS Letters, vol. 342, "Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes", pp. 281-285, 1994.
Tamamura, H., et al., Chemical and Pharmaceutical Bulletin, vol. 43, "Synthesis of protegrin-related peptides and their antibacterial and anti-Human Immunodeficiency Virus activity", pp. 853-858, 1995.
Zhao, C., et al., FEBS Letters, vol. 368, "The structure of porcine protegrin genes", 197-202, 1995.
Zhao, C., et al., FEBS Letters, vol. 376, "Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39", pp. 130-134, 1995.
Maloy, W. L., & Kari, U. P., Biopolymers(Peptide Science), vol. 37, "Structure-activity studies on magainins and other host defense peptides", pp. 105-122, 1995.
Masera, R. G., et al., Regulatory Peptides, vol. 62, "Corticostatins/defensins inhibit in vitro NK activity and cytokine production by human peripheral blood mononuclear cells", pp. 13-21, 1996.
Broekaert, W.F. et al., "Antimicrobial Peptides from Amaranthus caudatus Seeds with Sequence Homology to the Cysteine/Glycine-Rich Domain of Chitin-Binding Proteins," Biochemistry (1992) 31:4308-4314.
Cornelissen, B.J.C. et al., "Strategies for Control of Fungal Diseases with Transgenic Plants," Plant Physiol (1993) 101:709-712.
Diamond, G. et al., "Tracheal antimicrobial peptide, a cysteine-rich from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA," Proc Natl Acad Sci USA (1991) 88:3952-3956.
Elsbach, P. et al., "Bactericidal/permeability increasing protein and host defense against Gram-negative bacteria and endotoxin," Current Opinion in Immunology (1993) 5:103-107.
Hain, R. et al., "Disease resistance results from foreign phytoalexin expression in a novel plant," Nature (1993) 361:153-156.
Harwig, S.S.L. et al., "Prophenin-1, an exceptionally proline-rich antimicrobial peptide from porcine leukocytes," FEBS Letters (1995) 362(1):65-69.
Harwig, S.S.L. et al., "Determination of Disulphide Bridges in PG-2, an Antimicrobial Peptide from Porcine Leukocytes,"Journal of Peptide Science (1995) 3:207-215.
Hoess, A. et al., "Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 .ANG. resolution," EMBO Journal (1993) 12(9):3351-3356.
Kokryakov, V.N. et al., "Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins," FEBS Letters (1993) 327(2):231-236.
Lambert, J. et al., "Insect immunity: Isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides," Proc Natl Acad Sci USA (1989) 86:262-266.
Lehrer, R.I. et al., "Direct Inactivation of Viruses by MCP-1 and MCP-2, Natural Peptide Antibiotics from Rabbit Leukocytes," Journal of Virology (1985) 54(2):467-472.
Lehrer, R.I. et al., "Defensins: Endogenous Antibiotic Peptides of Animal Cells," Cell (1991) 64:229-230.
Lehrer, R.I. et al., "Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells," Annu Rev Immunol (1993) 11:105-28.
Matsuzaki, K. et al., "Role of Disulfide Linkages in Tachyplesin-Lipid Interactions," Biochemistry (1993) 32:11704-11710.
Mirgorodskaya, O.A. et al., "Primary structure of three cationic peptides from porcine neutrophils," FEBS Letters (1993) 330(3):339-342.
Miyata, T. et al., "Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity," J Biochem (1989) 106:663-668.
Morimoto, M. et al., "Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro," Chemotherapy (1991) 37:206-211.
Murakami, T. et al., "Direct Virus Inactivation of Tachyplesin I and Its Isopeptides from Horseshoe Crab Hemocytes," Chemotherapy (1991) 37:327-334.
Nakamura, T. et al., "Tachyplesin, a Class of Antimicrobial Peptide from the Hemocytes of the Horseshoe Crab (Tachypleus tridentatus)," The Journal of Biological Chemistry (1988) 263(32):16709-16713.
Nakashima, H. et al., "Anti-Human Immunodeficiency Virus Activity of a Possible Inhibitor of Virus-Cell Fusion," Antimicrobial Agents and Chemotherapy (1992) 36(6):1249-1255.
Rustici, A. et al., "Molecular Mapping and Detoxification of the Lipid A Binding Site by Synthetic Peptides," Science (1993) 259:361-365.
Selsted, M.E. et al., "Purification, Primary Structures,
Harwig Sylvia S. L.
Kokryakov Vladimir N.
Lehrer Robert I.
Moore William W.
University of California
Wax Robert A.
LandOfFree
Protegrins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protegrins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protegrins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1282232