Peptide antagonists at glutamate and NMDA receptors

Details Peptide antagonists at glutamate and NMDA receptors Peptide antagonists at glutamate and NMDA receptors

1995-11-09

1998-09-08

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 514 12, 514 13, A61K 3800, A61K 3828, A61K 3827, A61K 3804

Patent

active

058045503

ABSTRACT:
The invention relates to the use of a new type of peptide antagonists at glutamate receptors and a subtype of glutamate receptors (NMDA (N-methyl-D-aspartate)) for the manufacture of a medicament to influence the glutamate receptor and the NMDA-receptor controlled cells such as neurons or glial cells in the central nervous system.

REFERENCES:
patent: 5017557 (1991-05-01), Fabbri et al.
Sara et al., Identification of Gly-Pro-Glu (GPE), The Aminoterminal Tripeptide of Insulin-Like Growth Factor 1 which is Truncated in Brain, as a Novel Neuroactive Peptide, Biochemical and Biophysical Research Communications, vol. 165, No. 2, 1989, pp. 766-771.
Szabo et al., The Bovine Insulin-Like Growth Factor (IGF) Binding Protein Purified from Conditioned Medium Requires the N-Terminal Tripeptide in IGF-1 for Binding Biochemical and Biophysical Research Communications, vol. 151, No. 1, 1988, pp. 207-214.
Hiney et al., Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty.sup.1, Rapid Communication, Neuroendocrinology, 1991, vol. 54, pp. 420-423.
Bourguignon et al., Gonadal-Independent Development Changes in Activation of N-Methyl-D-Aspartate Receptors Involved in Gonadotropin-Releasing Hormone Secretion, Neuroendocrinology 1991, vol. 55, pp. 634-641.
Carone et al., Differences between in vitro and in vivo degradation of LHRH by rat brain and other organs, American Journal of Phys., vol. 253, 1987, pp. E317-E321.
Sasaki et al., Multiple Forms of Immunoreactive Growth Hormone-Releasing Hormone in Human Plasma, Hypothalamus, and Tumor Tissues, Journal of Clinical Endocrinology and Metabolism, vol. 68, No. 1, pp. 180-185.
Bourguignon et al., Gonadotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-D-aspartate receptors: a mode of autocrine regulation of peptide secretion, Chemical Abstracts, vol. 120:208955u, 1994, p. 148.

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