Method for purifying hepatitis B antigen

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195 15, 424 89, A61K 3912, C12K 500, C12K 700

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active

040173607

ABSTRACT:
Hepatitis B antigen useful as vaccine is prepared from clarified plasma of hepatitis B donors by treating with pepsin at a pH wherein pepsin is enzymatically active, treating with urea, and optionally treating with formaldehyde.

REFERENCES:
patent: 3636191 (1972-01-01), Blumberg
Houwen et al.-Chem. Abst. vol. 79 (1973) p. 64320t.
Geserick et al.-Chem. Abst. vol. 81 (1974) p. 36325w.

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