Substituted azabicycloalkanes, the use thereof, pharmaceutical c

Details Substituted azabicycloalkanes, the use thereof, pharmaceutical c Substituted azabicycloalkanes, the use thereof, pharmaceutical c

1987-07-28

1989-06-13

Rizzo, Nichola S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514412, 514299, 548452, 548453, C07D22122, A61K 31435

Patent

active

048393797

ABSTRACT:
1-Phenyl-3-azabicyclo[3.1.0]hexane-2,4-diones of the formula ##STR1## wherein R.sub.1 is hydrogen, R.sub.2 is hydrogen, sulfo or acyl and R.sub.3 is hydrogen, or R.sub.1 is a saturated or unsaturated aliphatic, cycloaliphatic or cycloaliphatic-aliphatic carbon radical of up to and including 18, preferably of up to and including 12, carbon atoms, R.sub.2 is hydrogen, lower alkyl, sulfo or acyl and R.sub.3 is hydrogen or lower alkyl, and to salts thereof, and salts thereof, have valuable pharmacological properties and are effective aromatase inhibitors. They can therefore be used for the treatment of hormonal diseases, in particular mammary carcinomas.

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