Calcification mitigation of implantable bioprostheses

Details Calcification mitigation of implantable bioprostheses Calcification mitigation of implantable bioprostheses

1987-04-17

1989-06-13

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Heart valve

Having rigid or semirigid pivoting occluder

8 9411, 128DIG8, 424 78, 514165, 623 1, 623 66, 623 11, A61F 224

Patent

active

048388882

ABSTRACT:
A process for treating biological tissue prior to implantation to mitigate the calcification of the tissue following implantation comprises incorporating acetylsalicylic acid into the tissue in an amount effective to reduce calcification of the tissue after it is implanted. In accordance with one embodiment, the process involves convalently binding the acetylsalicylic acid to the tissue via a coupling agent.

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Oblath et al., "Prevention of Platelet Aggregation and Adherence to Prosthetic Vascular Grats by Aspirin and Dipyridamole"; Surgery, Jul. 1978, pp. 37-44.
Lloyd et al.; "Coupling of Acrylic Polymers and Collagen by Use of Water Soluble Carbodiimide I" J. of Polymer Science:Polymer Chemistry Ed.; vol. 17, (1979) pp. 3459-3472.
Lloyd et al.; "Coupling of Acrylic Polymers and Collagen by Use of Water Soluble Carbodiimide II"; J. of Polymer Science:Polymer Chemistry Ed.; vol. 17; (1979) pp. 3473-3483.

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