4,7-dihydrothieno[2,3-B]pyridine derivatives useful in the treat

Details 4,7-dihydrothieno[2,3-B]pyridine derivatives useful in the treat 4,7-dihydrothieno[2,3-B]pyridine derivatives useful in the treat

1986-06-02

1987-10-27

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514301, 546 80, 546114, A61K 3144, C07D49504

Patent

active

047030518

ABSTRACT:
Highly effective calcium channel blockers having potent antihypertensive and coronary vasodilating actions, i.e. 4,7-dihydrothieno[2,3-b]pyridine derivatives of the formula: ##STR1## wherein R.sup.1 is straight or branched chain C.sub.1 -C.sub.4 alkyl, alkoxyalkyl, or arylalkyl; R.sup.2 is hydrogen, straight or branched chain C.sub.1 -C.sub.4 alkyl, or alkoxycarbonyl; R.sup.3 is hydrogen, straight or branched chain C.sub.1 -C.sub.4 alkyl, phenyl which may be substituted by one or more halogens or alkoxy groups, optionally substituted cycloalkyl, or optionally substituted cycloalkylalkyl; or R.sub.2 and R.sup.3 taken together may form an alkylene.

REFERENCES:
patent: 4532248 (1985-07-01), Franchowiak et al.
patent: 4562256 (1985-12-01), Adachi et al.

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