Formulation containing S(+) enantiomer of flurbiprofen or ketopr

Details Formulation containing S(+) enantiomer of flurbiprofen or ketopr Formulation containing S(+) enantiomer of flurbiprofen or ketopr

1991-05-28

1993-03-02

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Mouth treatment

514901, 514902, 514568, 514570, A01N 3710, A61K 3119

Patent

active

051909812

ABSTRACT:
A method of reducing bone loss and promoting bone regrowth, once loss has occurred, particularly alveolar bone loss associated wtih periodontal disease, and a composition useful in the method. The method comprises applying to buccal membranes a therapeutically effective quantity of at least one S enantiomer, generally an S(+) enantiomer, of a nonsteroidal anti-inflammatory drug, such as S(+) flurbiprofen or S(+) ketoprofen. The composition is a formulation which is a toothpaste or which is a mouthwash.

REFERENCES:
patent: 4569837 (1986-02-01), Suzuki et al.
patent: 4906670 (1990-03-01), Higashi et al.
patent: 4927854 (1990-05-01), Sunshine et al.
patent: 4933172 (1990-06-01), Clark, Jr. et al.
patent: 4975271 (1990-12-01), Dunn et al.
patent: 4996209 (1991-02-01), Aoki
Jeffcoat, et al., "Flurbiprofen Treatment of Human Periodontitis: Effect on Alveolar Bone Height and Metabolism", J. Periodont. Res. 23: 381-385 (1988).

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