Substituted dibenz-oxa-thiocinones, -12-oxides and -12,12-dioxid

Details Substituted dibenz-oxa-thiocinones, -12-oxides and -12,12-dioxid Substituted dibenz-oxa-thiocinones, -12-oxides and -12,12-dioxid

1991-11-26

1993-03-02

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 10, A61K 3139, C07D32700

Patent

active

051909715

ABSTRACT:
The invention relates to substituted dibenz-oxa-thiocinone-12-oxides and -12,12-dioxides of the general formula I ##STR1## in which R.sup.1 to R.sup.6 and Y have the meaning indicated in the description, to processes for their preparation and to their use in medicaments, in particular in circulation-influencing medicaments.

REFERENCES:
W. Lam et al., J. Am. Chem. Soc., "Diaryltetraoxypersulfuranes", 103, pp. 120-127 (1981).
W. Lam et al., J. Org. Chem., "Restricted Internal Rotations in Some Ortho-Substituted Diaryl Sulfides and Salfones," 46, pp. 4458-4462 (1981).
W. Lam et al., J. Org. Chem., "Ketalization of Dihydroxy Sulfones (8-S-4 Species) by Cyclodehydration," 46, pp. 4462-4468 (1981).
Urs T. Ruegg, "Ouabain--The Cause of Hypertension", Neue Zuricher Zeitung, Mar. 4, 1992.
Johannes-Peter Stasch, "Rapid Communication: Dynorphin Stimulates the release of ANP from isolated rat atria", Nov. 25, 1988, pp. 101-102.
James A. Pitcock, M.D., "Renomedullary Deficiency in Partial Nephrectomy-Salt Hypertension," in Hypertension, vol. 2, No. 3, 1980, pp. 281-290.
T. Sassa et al., "Structure of peniccilide, a new metabolite . . . ", Tetrahedron Letters, No. 45, (Nov. 1974), pp. 3941-3942.

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