Purified hematoporphyrin dimers and trimers useful in photodynam

Details Purified hematoporphyrin dimers and trimers useful in photodynam Purified hematoporphyrin dimers and trimers useful in photodynam

1990-09-18

1993-03-02

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540145, A61K 3140, C07D48722

Patent

active

051909669

ABSTRACT:
Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula ##STR1## wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.

REFERENCES:
patent: 4649151 (1987-03-01), Dougherty et al.
Lispon et al., J. National Cancer Inst. (1961) 26(1):1-10.
Dougherty et al., Adv. Exp. Med. Biol. (1983) 160:3-13.
Kessel et al., Photochem. Photobiol. (1987) 46(5):563-568.
Scourides et al., Cancer Res. (1987) 47:3439-3445.

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