Localization and characterization of the Wilms' tumor gene

Details Localization and characterization of the Wilms' tumor gene Localization and characterization of the Wilms' tumor gene

1991-11-20

1994-09-27

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 935 77, 935 78, 536 2431, C07H 2102, C07H 2104, C12Q 168

Patent

active

053508408

ABSTRACT:
The Wilms' tumor gene associated with the 11p13 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in a limited number of cell types (e.g., predominantly kidney cells and ja subset of hematopoietic cells). The polypeptide encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

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