Method for improving the biocompatibility of solid surfaces

Details Method for improving the biocompatibility of solid surfaces Method for improving the biocompatibility of solid surfaces

1993-01-19

1994-09-27

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

523112, 604266, 424409, 424422, A61F 254, A61F 202, A61K 922

Patent

active

053508009

ABSTRACT:
A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.

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