Tetrahydrocyclopent[B]indole methanamines and related compounds

Details Tetrahydrocyclopent[B]indole methanamines and related compounds Tetrahydrocyclopent[B]indole methanamines and related compounds

1993-03-08

1994-09-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548439, 548449, 544142, 544372, 546139, 546200, 5142328, 514253, 514307, 514320, C07D20980, C07D41302, A61K 3140, A61K 31535

Patent

active

053507622

ABSTRACT:
There are disclosed various compounds of the formula below, ##STR1## where the various parameters R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, m and n are as defined in the specification, which show activities as a monoamine oxidase inhibitor demonstrating a utility for the treatment of depression, and activities as a cholinesterase inhibitor demonstrating a utility for the treatment of various memory dysfunctions such as Alzheimer's disease.

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patent: 4128560 (1978-12-01), Asselin et al.
patent: 4235903 (1980-11-01), Dionne et al.
patent: 5100891 (1992-03-01), Ong et al.
Pugsley et al., Experentia vol. 33(1), pp. 57-59 (Jan. 1977).
Asselin et al., J. Med. Chem vol. 19(6), pp. 792-797 (Jun. 1976).
Humber, Demerson, Asselin, Charest, and Pelz; Eur. J. Med. Chem.-Chimica Therapeutica, May-Jun. 1975-10, No. 3, pp. 215-220.

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