HCV immunoassays employing C domain antigens

Details HCV immunoassays employing C domain antigens HCV immunoassays employing C domain antigens

1993-08-09

1994-09-27

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435975, 436512, 436518, 530300, 530327, 530326, 530328, 530812, 530876, 930220, 930223, C12G 170, C12G 168, A61K 3702, G01N 33543

Patent

active

053506715

ABSTRACT:
Immunoassays for the detection of antibodies to HCV are provided which employ "C" domain antigens. Immunoassay kits comprising such antigens are also provided.

REFERENCES:
patent: 4464474 (1984-08-01), Coursag et al.
patent: 4702909 (1987-10-01), Vilbrejos et al.
Arikan, et al. "Sequences of the E. coli evrB Gene and Protein", Nucleic Acids Res., 14(6):2637 (1986).
Bryan, "Viral Hepatitis, 1. Clinical and Laboratory Aspects and Epidemiology", Interstate Postorad, Med. USA, 68(5):66-86.
Okamoto, et al., "The 5'-Terminal Sequence of the Hepatitis C Virus Genome", Jon. J. Exp. Med., 60(3):167 (1990).
Old & Primrose, Principles of Gene Manipulation, 3rd Ed. (1985) Blackwell Scientific Publication, p. 113.
Schuurs, et al., "Enzyme Immunoassay", Clin. Chim. ACTA, 81: 1-40 (1977).
Shafritz, et al., "Monoclonal Radioimmunassays for Hepatitis B Surface Antigen: Demonstration of Hepatitis B Virus DNA or Related Sequences in Serum and Viral Epitopes and Immune Complexes", Proc. Nat'l. Acad. Sci. USA, 79:5675-5679 (1982).
Letter from Mr. Lanman of the NIH to Robert Blackburn of Chiron dated Oct. 16, 1989.

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