Novel pyridine derivatives

Details Novel pyridine derivatives Novel pyridine derivatives

1979-06-22

1981-06-09

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424263, 546257, 546270, 546304, C07D21332

Patent

active

042726280

ABSTRACT:
New 4-pyridinamine derivatives having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, [wherein one of R.sup.1 and R.sup.2 is aryl or heteroaryl, the other of R.sup.1 and R.sup.2 is lower alkyl, R.sup.3 and R.sup.4 are independently hydrogen or lower alkyl, and n is 0 or 1] are described. They show CNS activity and may used as antidepressant drugs. N-([.alpha.-Phenyl]-n-propyl)-4-pyridinamine also shows anti-ulcer activity.

REFERENCES:
patent: 2713048 (1955-07-01), Weston
patent: 4180670 (1979-12-01), Edington
Orcutt et al., Chem. Abst. vol. 44, col. 10156 (1950).
Huttrer et al., J. Am. Chem. Soc. 1999-2002 (1946).
Wade, Martindale The Extra Pharmacopoedia, pp. 1287-1309 (1977).
Carpendo et al., Chem. Abst. 73, abst, 108,061 (1970).
Kyrides et al, J. Am. Chem. Soc. vol. 72, pp. 745-748 (1950).
Vilani et al., J. Am. Chem. Soc. vol. 73, pp. 5916-5917 (1951).
Jain et al., J. Med. Chem. vol. 11, pp. 87-92 (1968).
Kato et al., Chemical Abstracts, vol. 46, abst. 4541a to d (1952).

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