Method for preparing the optically active isomer of 2,2-[[5-[3-[

Details Method for preparing the optically active isomer of 2,2-[[5-[3-[ Method for preparing the optically active isomer of 2,2-[[5-[3-[

1980-10-09

1982-04-20

Warren, Charles F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564157, C07C10324, C07C10328

Patent

active

043260764

ABSTRACT:
A method is provided for preparing the optically active isomer [2R-[2.alpha.,3.alpha.,5(R*)]]-2,2'-[[5-[3-[(1,1-dimethylethyl)amino]-2-hy droxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediyl]bis(oxy)]bis-[N,N-dipr opylacetamide] having the structure ##STR1## which is useful as an antiarrhythmic agent.

REFERENCES:
patent: 3935267 (1976-01-01), Hauck et al.
patent: 4165384 (1979-08-01), Carlsson et al.
Nelson et al., J. Org. Chem., vol. 42, No. 6, 1977, pp. 1006-1012.
Baldwin et al., J. Org. Chem., 43, (25 4876 (1978)).
Condon et al., J. Med. Chem., vol. 21, 1978, p. 913.
Borowitz et al., Organic Preparations and Procedures Int., 9(6), 1977, pp. 257-262.
Weiss, Synthetic Ionophores, Belfer Graduate Schoole of Science, Yeshiva University, 1976.

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