Process for preparation of folic acid derivatives

Details Process for preparation of folic acid derivatives Process for preparation of folic acid derivatives

1979-10-31

1982-04-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544259, 544260, C07D47506

Patent

active

043260608

ABSTRACT:
Folic acid derivatives, such as radiolabeled pteroyltyrosine, are conveniently synthesized from either pteroic acid or by the direct condensation of 6-formylpterin with p-aminobenzoyltyrosine methyl ester. The radioiodinated derivatives are particularly useful in competitive protein binding and radioimmuno-assays of folate compounds.

REFERENCES:
patent: 2821528 (1958-01-01), Sletzinger et al.
patent: 3972991 (1976-08-01), Caston
patent: 3989812 (1976-11-01), Barrett
patent: 4091087 (1978-05-01), Barrett

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