Antibacterial agents, and 4-thio azetidinone intermediates

Details Antibacterial agents, and 4-thio azetidinone intermediates Antibacterial agents, and 4-thio azetidinone intermediates

1979-09-21

1981-06-09

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602452R, 2602454, 2603409R, 2603433R, 2603303, 2603472, 2603459R, 260349, 544236, 546270, 546263, C07D20508, C07D40312, C07D51304, A61K 31425

Patent

active

042724376

ABSTRACT:
This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

REFERENCES:
patent: 3950357 (1977-04-01), Kahan
patent: 4000154 (1976-12-01), Gleason et al.
patent: 4051132 (1977-09-01), Firestone
patent: 4053468 (1977-10-01), Holden
patent: 4140688 (1979-02-01), Perchonock
patent: 4168314 (1979-09-01), Christensen
patent: 4182711 (1980-01-01), Veda
Eglington, J.C.S. Chem. Comm. 1967, 720.
Fisher et al., Ann. Reports Med. Chem., 13, 139-248 (1978).
Woodward et al., Acta Pharm. Suecica 14 (Supl.) 23 (1977).
Brown et al., J.C.S. Chem. Comm. 359-360 (1977).

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