Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com

Details Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com

1978-04-28

1979-04-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 21, 544 24, 544 26, 544 29, 544 30, 544 22, 424200, 424246, C07D50118

Patent

active

041502230

ABSTRACT:
Novel antibiotics of the formula: ##STR1## and its salts, esters and amides wherein R is acyl; B is H, OCH.sub.3, CH.sub.3 or SR" wherein R" is lower alkyl; A is hydrogen, hydroxy, or an organic group; and, Y is a radical of the formula PO(OH).sub.2 ; PO(OH)(OR") wherein R" is loweralkyl; SO.sub.2 (OH); or SO.sub.2 NH.sub.2.
The products are prepared by a multi-step process starting with an .alpha.-aminophosphonoacetate and terminating in the acylation of the 7-amino compound, and, if desired, removing the ester blocking group. The products are useful antibiotics.

REFERENCES:
patent: 3801567 (1974-04-01), Heusler et al.
patent: 3856785 (1974-12-01), Breuer et al.
patent: 3966719 (1976-06-01), Barth
patent: 4014872 (1977-03-01), Cocker

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