Certain pyrrole analogs of prostacyclin derivatives

Details Certain pyrrole analogs of prostacyclin derivatives Certain pyrrole analogs of prostacyclin derivatives

1980-02-19

1982-02-09

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26032627, 424274, 544238, 544298, 544405, 548187, 548225, 546272, A61K 3140, C07D20952, C07D40112, C07D40512, A61K 31435

Patent

active

043150136

ABSTRACT:
Prostane derivatives of the formula ##STR1## wherein R.sub.1 is (a) hydrogen, (b) C.sub.1-10 alkyl, (c) C.sub.1-10 alkyl substituted by halogen; C.sub.1-4 alkoxy; C.sub.6-10 aryl; C.sub.6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C.sub.1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C.sub.1-4 alkoxy group; di-C.sub.1-4 -alkylamino; or tri-C.sub.1-4 alkylammonium; (d) C.sub.4-10 cycloalkyl, (e) C.sub.4-10 cycloalkyl substituted by C.sub.1-4 alkyl, (f) C.sub.6-10 aryl, (g) C.sub.6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C.sub.1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C.sub.1-4 alkoxy group, or (h) an aromatic heterocycle of 5 or 6 ring atoms one of which is O, N or S;

REFERENCES:
patent: 4097489 (1978-06-01), Bundy
patent: 4151176 (1979-04-01), Bundy
patent: 4161584 (1979-07-01), Bundy
patent: 4211706 (1980-07-01), Bundy
Bundy et al., Tet. Letters, No. 16, pp. 1371-1374, (1978).

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