Process for preparing .beta.-lactam derivatives

Details Process for preparing .beta.-lactam derivatives Process for preparing .beta.-lactam derivatives

1999-03-11

2000-11-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D50108, C07D205095

Patent

active

061505196

ABSTRACT:
A process for preparing an allenyl .beta.-lactam compound represented by the formula (4), characterized by reacting the hydroxyl group of a .beta.-lactam compound represented by the formula (1) with a reactive functional group derivative of sulfonic acid represented by the formula (2) to convert the compound of the formula (1) to a .beta.-lactam compound represented by the formula (3), thereafter reacting the resulting .beta.-lactam compound with a basic anion exchange resin of the type having a tertiary organic base fixed to the resin and isolating the resulting allenyl .beta.-lactam compound of the formula (4) from the reaction mixture ##STR1##

REFERENCES:
patent: 5162521 (1992-11-01), Farina
patent: 5162524 (1992-11-01), Farina
patent: 5204458 (1993-04-01), Torii
patent: 5929233 (1999-07-01), Torii
Kant, J. Org. Chem 59, 4956, Jul. 1994.
Tanaka et al. Nippon Kaga Kukai #61, Spring Annuall Meeting 1991, Section C9, #46, p. 1832, with translation.
Tanaka, Syn. Lett. 1991, p. 888.
Kukolja, J. Org. Chem. 41, 2276 (1976).
Abstract for JP 4-282387 (1992).

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