Preparation of leurosidine and novel leurosidine 4'-ethers and e

Details Preparation of leurosidine and novel leurosidine 4'-ethers and e Preparation of leurosidine and novel leurosidine 4'-ethers and e

1976-05-17

1978-02-21

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424262, C07D47118

Patent

active

040752143

ABSTRACT:
Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with a lower alkanol or 4' esters of leurosidine perchlorate with acetic anhydride.

REFERENCES:
patent: 3205220 (1965-09-01), Svoboda et al.
Neuss et al., Tetrahedron Letters, No. 9, pp. 811-816, 1967.

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