Topical compositions for regulating the oily/shiny appearance of

Details Topical compositions for regulating the oily/shiny appearance of Topical compositions for regulating the oily/shiny appearance of

1998-10-08

2000-11-21

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3135

Patent

active

061504033

ABSTRACT:
The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.

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"Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid", J. Amer. Coll. Toxicology, M. A. Liebert, Inc., Publisher, vol. 4, No. 3, pp. 123-159 (1985).
Ogo, K., et al., "Antibactericidal Effect of Kankohso 201 on Propionibacterium, a Normal Anaerobic Flora on Human Skin", Dept. of Microbiology, Okayama U. Med. School, pp. 59-64 (1981)--Translation.
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