Nucleic acid detection probes having non-FRET fluorescence quenc

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435810, 436164, 436172, 436800, 536 243, 536 2431, 536 2432, C12Q 168, C07H 2104

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061500976

ABSTRACT:
Nucleic acid hybridization probes having a first conformation when not interacting with a target and a second conformation when interacting with a target, and having the ability to bring a label pair into touching contact in one conformation but not the other, are labeled with a non-FRET pair of chromophores and generate a fluorescent or absorbance signal. Kits may include such probes, and assays, including multiplex assays, may utilize such probes.

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