Method of controlling drug release by resonant sound wave

Details Method of controlling drug release by resonant sound wave Method of controlling drug release by resonant sound wave

1991-04-12

1993-03-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424491, 424493, 424499, 604 22, A61K 952

Patent

active

051907666

ABSTRACT:
A drug carrier carrying a drug is introduced to a diseased region of the living body while it is observed in the B mode echograms. The drug carrier is irradiated with an ultrasonic wave for strongly vibrating the drug carrier, thereby releasing the drug from the drug carrier for curing the diseased portion.

REFERENCES:
patent: 4825851 (1989-05-01), Cocks et al.
patent: 4892089 (1990-01-01), Cocks et al.
"Microcapsule Drug Delivery System as Micromachine Using Resonant Ultrasound", Japan Soc. ME and BE p. 49 (Oct. 1989).
"Localization of Sonodynamic Effect for Cancer Treatment: Study of Acoustic Chemical Therapy (II)" Proceedings of the 55th Meeting of Japan Society of Ultrasonics in Medicine, pp. 683-684 (1989).
"Combination Treatment of Ultrasound and Drug on Tumor", Proceedings of the 54th Meeting of the Japan Society of Ultrasonics in Medicine, pp. 257 to 258 (1989).
"Ultrasonic Control of Drug Releasing", Japan J. Artificial Organs, vol. 13, No. 3, pp. 1205 to 1208 (1989).
Ken Ishihara et al., "New Approach to Noninvasive Manometry Based on Pressure Dependent Resonant Shift of Elastic Microcapsules in Ultrasonic Frequency Characteristics", Japanese Journal of Applied Physics, vol. 27 (1988), Supplement 27-1, pp. 125-127.

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