Process for the preparation of trifluoropropanal

Details Process for the preparation of trifluoropropanal Process for the preparation of trifluoropropanal

1999-11-04

2000-08-29

Vollano, Jean F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564259, 568487, 568489, C07C24908

Patent

active

061111392

ABSTRACT:
A compound having the formula 3,3,3-trifluoropropanal oxime, and an improved process for forming 3,3,3-trifluoropropanal and its oxime. The process for producing 3,3,3-trifluoropropanal involves reacting an alkali or alkaline earth metal salt of an alcohol, which alcohol has the formula ROH, where R is a C.sub.1 -C.sub.4 alkyl, with CF.sub.3 CH.dbd.CHCl under conditions sufficient to yield a product mixture comprising at least one of CH.sub.3 CH.dbd.CHOR and CF.sub.3 CH.sub.2 CH(OR).sub.2 ; and then reacting the product mixture of with a C.sub.3 -C.sub.16 alkanoic acid, and heating under conditions sufficient to form 3,3,3-trifluoropropanal. The oxime is prepared by reacting hydroxylamine with 3,3,3-trifluoropropanal under conditions sufficient to produce 3,3,3-trifluoropropanal oxime.

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Hong, Feng, et al "A novel and convenient synthesis of (Z)-3,3,3-trifluoropropenyl alkyl ethers and CF.sub.3 substituted propyl acetals as verasatile CF.sub.3 -containing building blocks" J.Chem.Soc.Chem.Commun. 1996; p. 57-8.
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