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Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 31415

Patent

active

061109541

ABSTRACT:
The use of a non-acidic non-steroidal anti-inflammatory drug (NSAID) such as dipyrone in the manufacture of a medicament for use in the treatment of pain in humans by epidural or intrathecal injection.

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Alessandra Beirith, Adair R.S. Santos, Ana L.S. Rodrigues, Tania B. Creczynski-Pasa, and Joao B. Calixto, "Spinal and SupraspinalAntiociceptive Action of Dipyrone in Formalin, Capsaicin and Glutamate Tests. Study of the Mechanism of Action", European Journal of Pharmacology (1998).
Joseph F. Antognini, MD., "Intrathecal Acetylsalicylic Acid and Indomethacin are not Analygesic for a Supramaximal Stimulus", International Anesthesia Research Society, 1993.
M. Pellerin, F. Hardy, A. Abergel, D. Boule, J.H. Palacci, P. Babinet, L. NG Wingtin, J. Glowinski, J.-F. Amiot, D. Mechali, N. Colbert, M. Starkman, "Chronic Refractory Pain in Cancer Patients" La Presse Medicale, Sep. 19, 1987.
F. Molke Jensen, J.B. Dahl and C. Frigast, "Digest Spinal Effect of Intrathecal Acetaminophen on Visceral Noxious Stimulation in Rabbits" Acta Anaesthesiol Scand 1992.
Martindale The Extra Pharmacopoeia 30.sup.th Edition 1993 p. 13.

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