Prostaglandin analogues, process for their preparation and pharm

Details Prostaglandin analogues, process for their preparation and pharm Prostaglandin analogues, process for their preparation and pharm

1990-05-25

1992-04-28

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560116, 562498, 549465, 548452, C07C17700, A61K 31557

Patent

active

051090210

ABSTRACT:
The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE.sub.1 s, 6-keto-PGF.sub.1 s, PGI.sub.2 s, 6,9.alpha.-nitrilo-PGI.sub.1 s and 6,9.alpha.-methano-PGI.sub.2 s, having a specific steric configuration, which are replaced by an alkyl (C.sub.1 to C.sub.8)-substituted cycloalkyl (C.sub.4 to C.sub.7) group in (1S,S) form, in (1S,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.

REFERENCES:
patent: 4479966 (1984-10-01), Hayashi
Imaki, Adv. Prost Res. 19, pp. 666-9 (1988).

Affiliated with

Also associated with

Rating

Prostaglandin analogues, process for their preparation and pharm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostaglandin analogues, process for their preparation and pharm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostaglandin analogues, process for their preparation and pharm will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1249741