Thiol carboxylic acid derivatives and their use as collagenase i

Details Thiol carboxylic acid derivatives and their use as collagenase i Thiol carboxylic acid derivatives and their use as collagenase i

1990-04-30

1992-04-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514419, 514541, 514547, 514548, 514550, 514616, 544159, 544400, 560 9, 560145, 562426, 562556, A61K 31395, A61K 31215, A61K 3119, C07D29512

Patent

active

051090007

ABSTRACT:
Novel compounds of the formula (I), processes for their preparation and their use as collagenase inhibitors are described: ##STR1## in which R.sub.1 is hydroxy; alkoxy; aryloxy; aralkyloxy; --NR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are hydrogen or alkyl, or R.sub.6 and R.sub.7 together with the N-atom to which they are bonded form a 5- to 7-membered ring with an optional heteroatom; --NHCH(R.sub.8)COR.sub.9 is hydrogen; alkyl optionally substituted by hydroxy, alkoxy, --NR.sub.6 R.sub.7, quanidine; CO.sub.2 H, CONH.sub.2, SH, or S-alkyl; or CH.sub.2 --AR where Ar is optionally substituted aryl; and R.sub.9 is hydroxy, alkoxy or --NR.sub.6 R.sub.7.

REFERENCES:
patent: 4263293 (1981-04-01), Sundeen et al.
patent: 4595700 (1986-06-01), Donald et al.

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