Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-10-09
1992-04-28
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 45, 514114, 514563, 514667, 514922, A61K 3170, A61K 3166
Patent
active
051089939
ABSTRACT:
The administration of a pharmaceutical mixture consisting of the immunomodulator inosiplex or components thereof (p-acetamidobenzoic acid and inosine), and zidovudine (3'-azio-3'-deoxythymidine, AZT) makes it possible to remarkably increase the basal plasma levels and the plasma half-life of AZT in a patient suffering from AIDS. This permits lowering the dose of AZT administered daily (1,200 mg per diem), thus achieving an attendant decrease in the serious toxicity of AZT while maintaining AZT's therapeutic efficacy. The lower toxicity of the mixture compared with AZT alone now justifies AZT administration to asymptomatic HIV-seropositive patients to whom its administration to dated was deemed inadvisable because of AZT's serious toxicity.
REFERENCES:
patent: 4866035 (1989-09-01), Durette
Langtry et al., Drugs, vol. 37, pp. 408-450 (1989).
Strategies for antiviral therapy in AIDS, Mitsuya et al. Nature 325, 773 (1987).
Synergistic cytotoxic effect of AZT and recombinant interferon alpha on normal human bone marrow progenitor cells, Berman et al. Blood 74, 1281 (1989).
AIDS treatment news Apr. 1986-1989. p. 158.
Antiviral therapy in AIDS, Sandstrom et al., Drugs 34, 372 (1987) The toxicity of AZT in treatment of patients with AIDS and AIDS related complex Richman et al. New Engl. J. of Med. Jul. 23, 1987, p. 192.
Kishore G. S.
Page Thurman K.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
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