DNA sequence encoding mas onhcogene, polypeptides encoded theref

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 79, 435960, 435 6, 436813, G01N 33574, G01N 33535

Patent

active

053209419

ABSTRACT:
This invention provides a DNA sequence comprising an activated oncogene, said oncogene encoding a polypeptide capable of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice, said DNA sequence having a nucleotide sequence substantially as shown in FIGS. 3A and 3B.
The invention also concerns a polypeptide molecule encoded by an activated oncogene, said molecule having the properties of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice and further said polypeptide having an amino acid sequence substantially as shown in FIGS. 3A and 3B.
Finally, this invention provides a method for treating a tumor induced by an activated mas oncogene.

REFERENCES:
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4559311 (1985-12-01), Stenman et al.
patent: 4584278 (1986-04-01), Knauf
patent: 4686180 (1987-08-01), Coggin, Jr. et al.
Chemical Abstracts 101 (11), 1984, pp. 318-319, #86901h, Cline et al., "Oncogene Detection".

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