Method for size exclusion chromatography

Details Method for size exclusion chromatography Method for size exclusion chromatography

1992-02-03

1993-03-02

Therkorn, Ernest G.

Liquid purification or separation

Processes

Chromatography

2101982, 210635, 530417, B01D 1508

Patent

active

051906589

ABSTRACT:
An apparatus and a method for size exclusion chromatography is provided. The apparatus is a chromatographic column adapted for use in size exclusion chromatography by having dimensions suitable for size exclusion chromatography and by having a packing material comprising generally spherical particles having wedge-shaped macropores. Preferred particles are in the shape of lamellar and/or acicular crystals extending radially outwardly from a central core region and comprise aluminum oxide, aluminum hydroxide or a mixture thereof. The method involves passing a solution of macromolecules through a column adapted for size exclusion chromatography packed with such particles. The particles effectively and efficiently separate a wide range of macromolecules in decreasing order of their molecular weight.

REFERENCES:
patent: 4160728 (1979-07-01), Kirkland
patent: 4822593 (1989-04-01), Wilhelmy
patent: 4900537 (1990-02-01), Wilhelmy
patent: 5015373 (1991-05-01), Carr
patent: 5037795 (1991-08-01), Wieserman et al.
patent: 5100547 (1992-03-01), Hariman
B. G. Belenkii and L. Z. Vilenchik, "Methodological Problems of Gel-Permeation Chromatography (GPC)", Chapter 4, Modern Liquid Chromatography of Macromolecules, Elsevier (1983), pp. 149-163.

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