Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1997-08-04
1999-01-19
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C07C 4545
Patent
active
058615385
ABSTRACT:
A mixture formed from an alkoxy-2-naphthaldehyde (e.g., 6-methoxy-2-naphthaldehyde), acetone, and aqueous NaOH and/or KOH is heated at about 20.degree. to about 56.degree. C. for about 0.25 to about 2 hours such that the conversion of monoalkoxy-substituted 2-naphthaldehyde is at least 97% and the yield of (alkoxy-substituted 2-naphthyl)-3-buten-2-one is at least 95% based on the monoalkoxy-substituted 2-naphthaldehyde used in forming the mixture. The (alkoxy-substituted 2-naphthyl)-3-buten-2-one can be hydrogenated using, for example, a Pd/C catalyst to form the corresponding saturated ketone. The process enables efficient production of precursors of nabumetone and related pharmaceuticals by a clean, highly efficient reaction.
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Albemarle Corporation
Pippenger Philip M.
Reamer James H.
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