Hydroxymethyl-indolizidines and quinolizidines and their use as

Details Hydroxymethyl-indolizidines and quinolizidines and their use as Hydroxymethyl-indolizidines and quinolizidines and their use as

1990-03-30

1991-07-02

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514299, 546138, 546183, A61K 31435, A61K 3141, C07D45502

Patent

active

050286145

ABSTRACT:
The present invention describes a group of polyhydroxylated indolizidines and quinolizidines and their esters. These compounds are prepared starting from 2,6-dideoxy-2,6-dideoxy-2,6-imino-1,3,4,5-tetrakis-O- (phenylmethyl)-D-glycero-L-gulo-heptitol or a corresponding N-substituted compound. The compounds are useful in the treatment of diabetes and as .alpha.-glucosidase I inhibitors.

REFERENCES:
patent: 4797387 (1989-01-01), King
Nash et al., Tetrahedron, 44, 5959 (1988).
Nash et al., Tetrahedron Letters, 29(20), 2487 (1988).
Harris et al., Tetrahedron Letters, 30(42), 5685 (1989).
Nash et al., Phytochemistry, 29(1), 111 (1990).
Derwent Abstract 90-107660/14 (Issued May 16, 1990).
NTIS Report PB89-235071, Dec. 19, 1989 (U.S. Patent Application Serial No. 7/289,907, filed Dec. 23, 1988).

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