Dimeric fluorescent energy transfer dyes comprising asymmetric c

Details Dimeric fluorescent energy transfer dyes comprising asymmetric c Dimeric fluorescent energy transfer dyes comprising asymmetric c

1994-07-29

1996-10-15

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

546107, C07H 1900, C07D22112

Patent

active

055655548

ABSTRACT:
Novel fluorescent DNA-staining dyes are provided combining asymmetric cyanine azole-indolenine dyes, which provide for strong DNA affinity, large Stokes shifts and emission in the red region of the spectrum. The dyes find particular application in gel electrophoresis and for labels which may be bound to a variety of compositions in a variety of contexts.

REFERENCES:
patent: 5312921 (1994-03-01), Glazer et al.
Rye et al, W. Cleic, Acid. Res 20: 2803-2812 (1992).
Benson et al., Nucleic Acids Research (1993) 21:5720-5726.
Hamer, "The Cyanine Dyes in Related Compounds," in The Chemistry of Heterocyclic Compounds, vol. 18, pp. 210-239 (Interscience Publishers, New York, 1964).
Ernst et al., Cytometry (1989) 10: 3-10.

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